You can get to the town center by Plzenska street by car or tram in less then 10 minutes.
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Directions:

From the Airport by public transport:

Take the bus #179 ( in front of the terminal) from the airport to the stop called MOTOL. Switch to a tram (streetcar) (all numbers will do) and go 5 stops towards the centre (downhill, eastward) to a stop called KAVALIRKA. After getting off at Kavalirka, walk back about 50 metres to the traffic lights, cross the main wide PLZENSKA street, take the first right hand turn and the first street to the left then is KE KLIMENTCE. Our house is number 14 (opposite to a modern apartment building called Residence Klimentka). You will need the 26,– CZK travel pass per person for your ride. It must be validated in a little yellowish machine right after you enter the bus (only once for the whole trip).

From the train station by public transport:

There are two international train stations in Prague: PRAHA – HLAVNI NADRAZI (the Main Station) and PRAHA – HOLESOVICE. They both are on the Red © line of the metro (subway). You need to go by metro (The Red line) from the train station to I.P.PAVLOVA stop. From here take the tram number 10 or 16 (the end station shown on the front will be SIDLISTE REPY or KOTLARKA), going down the hill. You need to get off at KAVALIRKA stop (on your way you will cross the river and pass the ANDEL Shopping Center). After getting off at Kavalirka, walk a little further (about 100 metres in the direction where the tram continues), take the first right hand turn (at the traffic lights) and the first street to the left then is KE KLIMENTCE. The number is 14 (opposite to a modern apartment building called Residence Klimentka). In the case you will arrive to The Main Station (HLAVNI NADRAZI), you can do the same combination with metro or you can go directly by tram no 9. The stop is about 5 minutes walk to the right through the park in front of the train station. The correct direction is to SIDLISTE REPY (the tram has a sign in front). You will get off at KAVALIRKA stop. You need to have the 26,– CZK ticket per person for the ride. It must be validated in a little yellow machine at the entrance to the metro or in the tram (only once for the whole way).

Driving directions:

From the South-East – Vienna, Salzburg, Brno, Ceske Budejovice:

You will be arriving to Prague via motorway D1 (E55). Follow the signs to the center. On your right hand side will be the high building of Corinthia Towers Hotel and immediately after it you will cross more than half kilometer long bridge. On the third traffic lights after that, turn left into ZITNA street.This will bring you down to the vast open space (KARLOVO MAMESTI). At the lower side, the traffic will turn left and after 100 metres right again. This street (RESSLOVA) will bring you down to the river, you need to cross the bridge. The signs are to PLZEN, KARLOVY VARY. Follow all the time the main traffic, this will bring you to PLZENSKA street. The street will go slightly up the hill. When it comes to the top, there will be the green park (KLAMOVKA) on your right hand side. Then on the left side big blue bulding and 200 metres futher, Hotel Kavalirka. On the first traffic lights after that turn right and the first street to the left is Ke Klimentce. We are number 14 (opposite to a modern apartment building called Residence Klimentka). Map

From the West – Frankfurt, Nurnberg, Pilsen:

You will be arriving to Prague via motorway E50 (D5). Follow the signs to the center. The motorway changes into a wide street called BUCHAROVA, you will pass 2 traffic lights, drive down the hill and at the third traffic lights you need to turn right into PLZENSKA street (2 lanes in each direction and a tram/streetcar track in the middle). After about 1 km you will pass on your right hand side the OMV gas station. At the second traffic lights after it you should turn left, but that is not allowed, so you need to turn right, turn around and cross the PLZENSKA street straight. The first street to the left is then Ke Klimentce. We are number 14 (opposite to a large modern apartment building called Residence Klimentka). Map

From the North – Berlin, Dresden, Teplice:

You will be arriving to Prague via motorway E55 (D8). Follow the signs to the center (there also will be signs to BRNO). You will get on multilane street called Wilsonova, going North-South direction through the city. There will be STÁTNÍ OPERA (State Opera House and the big building of The National Museum on your left hand side and at that point Wenceslas Square with the riding statue of St Wenceslas on your right hand side. At the next traffic lights turn right into ZITNA street.This will bring you down to the vast open space (KARLOVO MAMESTI). At the lower side, the traffic will turn left and after 100 metres right again. This street (RESSLOVA) will bring you down to the river, you need to cross the bridge. The signs are to PLZEN, KARLOVY VARY. Follow all the time the main traffic, this will bring you to PLZENSKA street. The street will go slightly up the hill. When it comes to the top, there will be the green park (KLAMOVKA) on your right hand side. Then on the left side big blue bulding and 200 metres futher, Hotel Kavalirka. On the first traffic lights after that turn right and the first street to the left is Ke Klimentce. We are number 14 (opposite to a large modern apartment building called Residence Klimentka). Map